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Multiple sclerosis: Rituximab shows promise: A drug therapy currently used to treat non-Hodgkin�s lymphoma and rheumatoid arthritis had a significant effect in treating the most common form of multiple sclerosis in a small, short-term clinical trial. Because the drug targets the immune system�s B-cells, rather than the immune system�s trad...
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Statins do not increase the risk of amyotrophic lateral sclerosis: The FDA's analysis has provided new evidence that the use of statins does not increase incidence of amyotrophic lateral sclerosis ( ALS ), a neurodegenerative disease often referred to as Lou Gehrig's Disease. The FDA analysis, undertaken after the agency received a higher than expected number o...
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Relapsing-remitting multiple sclerosis: Rituximab shows promise: A drug therapy currently used to treat non-Hodgkin�s lymphoma and rheumatoid arthritis had a significant effect in treating the most common form of multiple sclerosis in a small, short-term clinical trial. Because the drug targets the immune system�s B-cells, rather than the immune system�s trad...
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Rimonabant: safety issues: Rimonabant ( Acomplia / Zimulti ) is a cannabinoid receptor antagonist. It acts by blocking a specific type of receptor called cannabinoid type 1 ( CB1 ) receptors. These receptors are found in the nervous system and are part of the system that the body uses to control food intake. By blocking the r...
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Women in polluted areas at higher risk of cardiovascular disease: Women living in areas with higher levels of air pollution have a greater risk of developing cardiovascular disease and subsequently dying from cardiovascular causes, according to a study published in The New England Journal of Medicine ( NEJM ). The study is one of the largest of its kind, involvin...
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Risk alleles for multiple sclerosis identified: A large-scale genomic study has uncovered new genetic variations associated with multiple sclerosis, findings that suggest a possible link between multiple sclerosis and other autoimmune diseases. The study, led by an international consortium of clinical scientists and genomics experts, is the fir...
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Minocycline for the treatment of neurodegenerative diseases: Researchers at the San Francisco VA Medical Center ( SFVAMC ) have identified the mechanism by which Minocycline ( Minocin ), a medication currently being studied for the treatment of neurodegenerative diseases including Parkinson's disease and Huntington's disease, protects brain and nerve cells fr...
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Variations in detoxifying genes linked to amyotrophic lateral sclerosis: Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis ( ALS, or Lou Gehrig's disease ), and possibly responsible for a reported twofold inc...
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Stem cells found in adult skin can be transplanted and function in mouse models of disease: Researchers at The Hospital for Sick Children ( SickKids ) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease. The research is published in The Journal of Neuroscience....
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ACE inhibitors may benefit patients with atherosclerosis: Angiotensin-converting-enzyme ( ACE ) inhibitors reduce cardiovascular mortality and morbidity in patients with heart failure or left ventricular systolic dysfunction. Researchers, led by Gilles R Dagenais of Laval University Heart and Lung Institute ( Canada ) undertook a systematic review of H...
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