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Anticholinergic drugs may increase cognitive decline in older people: A study looked at the effects of taking a medication with anticholinergic properties on the annual change in thinking abilities of 870 Catholic nuns and clergy members who were an average of 75 years old. All of the participants were part of the Rush Religious Orders Study, an ongoing, longitudinal,...
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EN101 antisense reduces the severity of muscle weakness in myasthenia gravis: A new type of treatment significantly reduces the severity of muscle weakness in myasthenia gravis, giving hope for a new class of drugs to treat neurological disorders, according to a study published in the Neurology. The drug, oral EN101 antisense, inhibits the production of acetylcholine ester...
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Nicotine exposure during development leads to hearing problems: Researchers know that children of women who smoke during pregnancy can develop hearing-related cognitive deficits. For the first time, researchers believe they have evidence that not only implicates nicotine as the culprit, but also shows what the substance does to the brain to cause these deficits....
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Increased sensitivity to nerve signals might offer a new approach to diabetes: Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood glucose control. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said. Mice in which the pancreas cells, that ...
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Alzheimer's disease: THC inhibits the enzyme acetylcholinesterase: Researchers at The Scripps Research Institute have found that the active ingredient in marijuana, tetrahydrocannabinol or THC, inhibits the formation of amyloid plaque, the primary pathological marker for Alzheimer's disease. The study is published in the journal Molecular Pharmaceutics, a public...
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Botox as an adjuvant to cancer therapy: A study, published in the Clinical Cancer Research, has showed that Botox may have a new use as an adjuvant to cancer therapy, providing an open door for chemotherapy and radiation treatments. The study in mice, led by Bernard Gallez, at the Universit� de Louvain in Brussels, Belgium, found that...
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Insulin levels drop with progression of Alzheimer's disease: Researchers at Rhode Island Hospital and Brown Medical School have discovered that insulin and its receptors drop significantly in the brain during the early stages of Alzheimer's disease, and that levels decline progressively as the disease becomes more severe. They also found that acetylcholine d...
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Air pollution can cause cardiovascular disease: Researchers at the New York University School of Medicine provide some of the most compelling evidence yet that long-term exposure to air pollution--even at levels within federal standards--causes heart disease. Previous studies have linked air pollution to cardiovascular disease but until now it wa...
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Anti-inflammatory activity of Alzheimer's disease drugs discovered: The mechanism of anti-Alzheimer's disease drugs that inhibits the production of a destructive, inflammation-causing protein in the brain has been revealed by researchers at the Hebrew University of Jerusalem. Their work, described in the Annals of Neurology, is likely to lead to the development ...
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Mild cognitive impairment, no benefit from Donepezil after three years: Researchers of the Alzheimer's Disease Cooperative Study evaluated the effect of Vitamin E and Donepezil, an acetylcholinesterase inhibitor, in the progression from mild cognitive impairment ( MCI ) to Alzheimer�s disease. Mild cognitive impairment is a transitional state between the cognitive c...
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