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Modified-release oral opioids of the WHO level III scale for the management of pain: benefits of most of these medicines outweigh risks: The EMA ( European Medicines Agency ) has finalised a review of modified-release oral opioids of the WHO level III scale for the management of pain. The Agency�s Committee for Medicinal Products for Human Use ( CHMP ) has concluded that the benefits of most of these medicines continue to outweigh th...
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Heterozygous familial hypercholesterolemia: Crestor for use in pediatric patients: The FDA ( Food and Drug Administration ) has approved Crestor ( Rosuvastatin calcium ) for use in pediatric patients ages 10-17 with heterozygous familial hypercholesterolemia ( HeFH ) when diet therapy fails to reduce elevated cholesterol. Heterozygous familial hypercholesterolemia, a genetic d...
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Pregnancy alone is not associated with increased risk for mental disorders: Pregnancy alone does not appear to be associated with an increased risk of the most prevalent mental disorders. However, post-partum women may have a higher risk of major depressive disorder. Pregnant women and those who have recently given birth are said to be exceedingly vulnerable to psychiat...
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Alcohol dependence: Naltrexone associated with severe injection site reactions: The FDA ( Food and drug Administration ) has informed healthcare professionals of the risk of adverse injection site reactions in patients receiving Naltrexone ( Vivitrol ). Physicians should instruct patients to monitor the injection site and contact them if they develop pain, swelling, tenderne...
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Head and neck cancer: Cetuximab in combination with Docetaxel and Cisplatin as induction therapy: Patients treated for locally advanced head and neck cancer may respond better to treatment with the addition of Cetuximab ( Erbitux ) to chemotherapy, according to a phase II study. In the study, 39 patients with stages 3 or 4 head and neck cancer were treated initially with a combination of Doc...
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Brain aneurysm: smokers treated with coils at higher risk of recurrence: Cigarette smokers who were treated for cerebral aneurysms with coil embolization are at greater risk of developing another aneurysm. In a paper published in the Journal of Neurosurgery, researchers at Jefferson Hospital for Neuroscience in Philadelphia, found there was an increased risk of recan...
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Zolpidem: adverse neurological and psychiatric reactions: The February 2007 Australian Adverse Drug Reactions Bulletin again alerted prescribers to an association found between Zolpidem ( Ambien, Stilnox ) and adverse neurological and psychiatric reactions, including changes in behaviour and mental state as well as specific effects such as sleep walking, a...
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Hepatitis C: Peginterferon alfa-2a reduces the virus but serious liver problems may progress: Patients with chronic hepatitis C and advanced liver disease who did not respond to previous standard therapy experienced significant decreases in their liver enzymes, viral levels, and liver inflammation following treatment with long-term pegylated Interferon. However, the treatment did not slow or...
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Effectiveness of most post-traumatic stress disorder therapies is uncertain: Many people, including significant proportions of active duty military personnel and veterans, suffer from post-traumatic stress disorder ( PTSD ), often in conjunction with other injuries or illnesses. While several drugs and psychotherapies are used to treat PTSD, many of the studies concerning th...
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Women with high or increasing blood pressure are up to three times more likely to develop diabetes: The Women�s Health Study has found that women who have high blood pressure levels are three times more likely to develop diabetes than women with low blood pressure levels. This effect was independent of body mass index and other conditions that are known to predispose people to cardiovascular dis...
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