Pan-cancer analysis of nearly 2,600 gynecologic and breast tumors has revealed five previously unknown subtypes
Researchers from The University of Texas MD Anderson Cancer Center have found a startling amount of new information about molecular features of tumors as well as identified previously unknown cancer subtypes based on a comprehensive analysis of 2,579 tumors from breast and four different types of gynecologic cancers. These new findings potentially could serve as a launching pad for future therapeutic studies.
Results from the multi-institutional effort were published in the Cancer Cell.
The study is part of the Pan-Cancer Atlas, which has aimed to answer overarching questions about cancer by examining the full set of tumors available via The Cancer Genome Atlas ( TCGA ), a joint effort of the National Cancer Institute ( NCI ) and the National Human Genome Research Institute ( NHGRI ).
The Pan-Can Atlas and TCGA aims of mapping key genomic changes in an array of cancer types, were to identify shared and unique molecular features, clinically significant subtypes and potential therapeutic targets.
Researchers have confirmed similarities previously identified in the five breast and gynecologic tumor types and discovered intriguing molecular relationships not observed in previous studies of these diseases.
A number of the observations have possible prognostic and/or therapeutic relevance, although any clinical possibilities illuminated by this study would require extensive additional research before they would be ready for practical application.
Key results of the study included:
using 16 key molecular features, researchers identified five prognostic cancer subtypes and developed a decision tree that classified patients into the subtypes based on six features assessable in clinical laboratories;
identifying other subtypes with high leukocyte counts, raising potential implications for immunotherapy treatment in the future;
discovering the presence of significant estrogen receptor-regulated long non-coding RNAs ( lncRNAs ) and interaction networks between genes and lncRNAs;
observing many genetic aberrations including 61 somatic copy-number alterations ( SCNAs ) and 46 significantly mutated genes ( SMGs ). Eleven each of the SCNAs and SMGs had not been identified in previous TCGA studies of five tumor types. ( Xagena )
Source: The University of Texas MD Anderson Cancer Center, 2018