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Anti-HIV drug combination does not increase preterm birth risk

A drug combination aimed at preventing transmission of HIV from a pregnant woman to her fetus likely does not increase the risk for preterm birth and early infant death, according to a re-analysis of ... read article

Pan-cancer analysis of nearly 2,600 gynecologic and breast tumors has revealed five previously unknown subtypes

Researchers from The University of Texas MD Anderson Cancer Center have found a startling amount of new information about molecular features of tumors as well as identified previously unknown cancer s ... read article

Efficacy of cinnamon in patients with type II diabetes mellitus

Multiple studies have evaluated the hypoglycemic effect of cinnamon in patients with diabetes mellitus type II, with conflicting results. Differences in baseline body mass index ( BMI ) of patient ... read article

Learning curve and established phase for uniportal VATS lobectomies: the Papworth experience

Uniportal video-assisted thoracoscopy ( VATS ) has increasingly gained importance in the thoracic surgery scenario. The use of this technique can reduce postoperative pain and length of stay and gives ... read article

Concussion in teenagers increases the risk of multiple sclerosis in later life

Concussion in teenagers increases the risk of multiple sclerosis in later life. However, there is no association with multiple sclerosis for concussion in younger children. The results have demonstr ... read article

Breast cancer may be more aggressive in patients with obesity

Women with obesity are more likely to get breast cancer, and a number of studies have provided a reasonable explanation why: after menopause, fat tissue manufactures estrogen, and the estrogen then pr ... read article

P/LAIV, a pandemic influenza vaccine has received positive CHMP opinion

The Committee for Medicinal Products for Human Use ( CHMP ) of the European Medicines Agency ( EMA ) has issued a positive opinion recommending the conditional approval of Pandemic Live Attenuated Inf ... read article

ANGPTL4 inhibition associated with reduced risk of coronary artery disease

The New England Journal of Medicine ( NEJM ) has published a paper showing that inactivating mutations of the angiopoeitin-like 4 ( ANGPTL4 ) gene are associated with a significantly reduced risk of c ... read article

Symptoms of insomnia in psoriasis are directly mediated by pruritus and pain

Psoriasis is an immune-mediated chronic inflammatory disorder which manifests as dermatologic lesions, and psoriatic arthritis in about 30% of cases. Psoriasis is associated with multiple comorbid ... read article

High-normal blood pressure in young adults linked to risk of heart failure in later life

Mild elevations in blood pressure considered to be in the upper range of normal during young adulthood can lead to subclinical heart damage by middle age, a condition that sets the stage for full-blow ... read article

Smog may be associated to heart disease only in patients with previously diagnosed coronary artery disease

Analyzing more than 16,000 myocardial infarctions that were treated in the Salt Lake City area of Utah ( U.S.A ) from 1993 to 2014, researchers found a significant association between days that had po ... read article

Multiple sclerosis: chemokine receptor CCR2, a key protein involved in a super-inflammatory immune response

Published in the journal Nature Communications, the researchers at the University of Adelaide have identified a key protein involved in a super-inflammatory immune response that drives the progression ... read article

Risk of sudden cardiac death associated with chronic obstructive pulmonary disease

People suffering COPD ( chronic obstructive pulmonary ) disease have an increased risk of sudden cardiac death ( SCD ), according to new research published online in the European Heart Journal. Wh ... read article

Response to statins influenced by genetic variants

A large analysis of over 40,000 individuals undergoing statin treatment has revealed two new genetic variants that may affect how low density lipoprotein ( LDL ) cholesterol responds to statin therapy ... read article

Non-small cell lung cancer: Afatinib provides more than one year additional survival in patients with the most common type of EGFR mutation ( del19 ) compared to chemotherapy

Boehringer Ingelheim has announced results of the pre-specified individual, as well as the exploratory combined, analyses of two phase III trials ( LUX-Lung 3 and LUX-Lung 6 ). These data have demonst ... read article

Focus

Multiple sclerosis: FDA has approved Tecfidera

The FDA ( Food and Drug Administration ) has approved Tecfidera ( Dimethyl fumarate ) capsules to treat adults with relapsing forms of multiple sclerosis.Multiple sclerosis is a chronic, inflammatory, ... read article

Apremilast linked to significant and clinically meaningful improvements for the primary and major secondary endpoint in plaque psoriasis

Celgene has announced that statistical significance for the primary endpoint of PASI 75 at week 16 was achieved for patients receiving Apremilast 30 mg BID monotherapy in both the ESTEEM 1 and 2 phase ... read article

Kadcyla, a new treatment for late-stage breast cancer, approved by Food and Drug Administration

The U.S. Food and Drug Administration ) has approved Kadcyla ( Ado-Trastuzumab Emtansine ), a new therapy for patients with HER2-positive, late-stage ( metastatic ) breast cancer.HER2 is a protein inv ... read article

FISSION and NEUTRINO trial: Sofosbuvir has met primary endpoints for hepatitis C

Results from two Phase 3 studies, FISSION and NEUTRINO, evaluating a 12-week course of the once-daily nucleotide Sofosbuvir in combination with Ribavirin ( FISSION ) and in combination with Ribavirin ... read article

FDA has approved Eliquis to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation

The FDA ( Food and Drug Administration ) has approved the anti-clotting drug Eliquis ( Apixaban ), an oral tablet used to reduce the risk of stroke and dangerous blood clots ( systemic embolism ) in p ... read article

Chronic hepatitis C: Promacta for patients with thrombocytopenia to allow the initiation and maintenance of Interferon-based therapy

GlaxoSmithKline ( GSK ) has announced that the FDA ( Food and Drug Administration ) has approved Promacta ( Eltrombopag; in Europe: Revolade ) for the treatment of thrombocytopenia in patients with ch ... read article

Bosulif for chronic myelogenous leukemia, approved by Food and Drug Administration

The FDA ( Food and Drug Administration ) has approved Bosulif ( Bosutinib ) to treat chronic myelogenous leukemia ( CML ), a blood and bone marrow disease that usually affects older adults.An estimate ... read article

Increased risk of high-grade prostate cancer with 5-alpha reductase inhibitors

Men aged 55 and over with a normal digital rectal examination and PSA less than or equal to 3.0 ng/mL at baseline taking Finasteride 5 mg/day ( 5 times the dose of Propecia ) in the 7-year Prostate Ca ... read article