MedicineNews.net - Medical Updates

Nonalcoholic steatohepatitis: farnesoid X receptor agonists

Data from a phase 2 randomized, placebo-controlled trial of the investigational, selective, non-steroidal farnesoid X receptor ( FXR ) agonist GS-9674 were presented at The Liver Meeting 2018 in San F ... read article

Platinum-resistant / refractory ovarian cancer: Avelumab alone or in combination with pegylated liposomal Doxorubicin did not meet the primary endpoints of overall survival or progression-free survival

The phase III JAVELIN Ovarian 200 trial evaluating Avelumab ( Bavencio ) alone or in combination with pegylated liposomal Doxorubicin ( PLD ), a type of chemotherapy, compared with PLD did not meet th ... read article

Lurbinectedin has shown noteworthy clinical activity in metastatic breast cancer with mutations in BRCA 1/2

Lurbinectedin ( Zepsyre ) has shown noteworthy clinical activity in patients with metastatic breast cancer that have mutations in the BRCA 1 and/or BRCA 2 genes. A phase II trial has assessed the c ... read article

Tivozanib in combination with Nivolumab in renal cell carcinoma: interim results from phase 2 portion of the TiNivo trial

Updated interim results from the phase 2 portion of the TiNivo study, a phase 1b/2 multicenter trial of oral Tivozanib ( Fotivda ) in combination with intravenous Nivolumab ( Opdivo ), an immune check ... read article

Cosentyx label update in European Union to include dosing flexibility in psoriatic arthritis

The European Commission has approved a label update for Cosentyx ( Secukinumab ). Cosentyx is the first and only fully-human treatment that specifically inhibits interleukin-17A ( IL-17A ), in psoriat ... read article

Larotrectinib, a TRK inhibitor, in children and adults patients with NTRK fusion cancer

Larotrectinib is being investigated to potentially treat adult and pediatric patients with locally advanced or metastatic solid tumors with a neurotrophic tyrosine receptor kinase ( NTRK ) gene fusion ... read article

Tanezumab for the treatment of osteoarthritis pain

A 16-week phase 3 study in patients with osteoarthritis pain evaluating subcutaneous administration of Tanezumab, an investigational humanized monoclonal antibody, met all three co-primary endpoints. ... read article

First two CAR-T cell medicines approved in the European Union: Kymriah and Yescarta

The European Commission ( EC ) has approved the first two marketing authorisations for chimeric antigen receptors ( CAR ) T-cells medicines in the European Union ( EU ). Kymriah ( Tisagenlecleucel ... read article

SOLAR-1 trial: alpha-specific PI3K inhibitor Alpelisib has met primary endpoint in HR+/HER2- advanced breast cancer with PIK3CA mutation

The global phase III SOLAR-1 trial evaluating the investigational alpha-specific PI3K inhibitor Alpelisib ( BYL719 ) has met the primary endpoint showing an improvement in progression-free survival ( ... read article

TRANSITION trial: Entresto can be safely initiated shortly after an acute heart failure episode

Data from the TRANSITION study presented at the European Society of Cardiology ( ESC ) Congress in Munich, Germany, have shown that Entresto ( Sacubitril / Valsartan ) can be initiated early and safel ... read article

FDA has approved Rituxan for pemphigus vulgaris

The FDA ( U.S. Food and Drug Administration ) has approved Rituxan ( Rituximab ) for the treatment of adults with moderate to severe pemphigus vulgaris, a rare, serious, potentially life-threatening c ... read article

ARCTIC trial in third-line non-small cell lung cancer: Durvalumab monotherapy showed a clinically-meaningful reduction in the risk of death compared to chemotherapy

Results from the phase III ARCTIC trial in patients with locally-advanced or metastatic non-small cell lung cancer ( NSCLC ) who have received at least two prior treatments, were announced. This rand ... read article

Pembrolizumab improves overall survival and progression-free survival as first-line treatment for squamous non-small cell lung cancer (NSCLC) in KEYNOTE-407 trial

The pivotal phase 3 KEYNOTE-407 trial investigating Pembrolizumab ( Keytruda ), an anti-PD-1 therapy, in combination with Carboplatin-paclitaxel or nab-Paclitaxel, as first-line treatment for metastat ... read article

Tivozanib, a VEGF tyrosine kinase inhibitor, for the treatment of adult patients with advanced renal cell carcinoma

Tivozanib ( Fotivda ) is an oral, once-daily, vascular endothelial growth factor ( VEGF ) tyrosine kinase inhibitor ( TKI ) for the treatment of adult patients with advanced renal cell carcinoma ( RCC ... read article

Symdeko to treat the underlying cause of cystic fibrosis in people ages 12 and older with certain mutations in the CFTR gene: FDA approved

The U.S. Food and Drug Administration ( FDA ) has approved Symdeko ( Tezacaftor / Ivacaftor and Ivacaftor ) for treating the underlying cause of cystic fibrosis in people ages 12 and older who have tw ... read article